Publications

Structural basis of pH-dependent activation in a CLC transporter

Eva Fortea, Sangyun Lee, Rahul Chadda, Yiorgos Argyros, Priyanka Sandal, Robyn Mahoney-Kruszka, Hatice Didar Ciftci, Maria E. Falzone, Gerard Huysmans, Janice L. Robertson, Olga Boudker & Alessio Accardi

Nature, Published: January 26, 2024

https://doi.org/10.1038/s41594-023-01210-5

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A thermodynamic analysis of CLC transporter dimerization in lipid bilayers

Rahul Chadda, Taeho Lee, Robyn Mahoney-Kruszka, Elizabeth G. Kelley, Nathan Bernhardt, Priyanka Sandal, and Janice L. Robertson

PNAS, Published: October 3, 2023

https://doi.org/10.1073/pnas.2305100120

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Mitigation of membrane morphology defects explain stability and orientational specificity of CLC dimers

Tugba N. Ozturk, Nathan Bernhardt, Noah Schwartz, Rahul Chadda, Janice L. Robertson, José D. Faraldo-Gómez

Preprint, bioRxiv: March 20, 2023

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Dimerization mechanism of an inverted-topology ion channel in membranes

Melanie Ernst, Esam A. Orabi, Randy B. Stockbridge, José D. Faraldo-Gómez, Janice L. Robertson

Preprint, bioRxiv: January 28, 2023

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A single-molecule method for measuring fluorophore labeling yields for the study of membrane protein oligomerization in membranes

Melanie Ernst, Tugba N. Ozturk & Janice L. Robertson

PLOS ONE, Published: January 20, 2023

https://doi.org/10.1371/journal.pone.0280693

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The Role of the Membrane in Transporter Folding and Activity

Melanie Ernst and Janice L. Robertson

Journal of Molecular Biology, Volume 433, Issue 16, 6 August 2021, 167103

https://doi.org/10.1016/j.jmb.2021.167103

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Localization Atomic Force Microscopy

George R. Heath, Ekaterina Kots, Janice L. Robertson, Shifra Lansky, Georfe Khelashvili, Harel Weinstein & Simon Scheuring

Nature 594, 385–390 (2021)

https://doi.org/10.1038/s41586-021-03551-x

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Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface

Kacey Mersch, Tugba N.Ozturk, Kunwoong Park, Hyun-HoLim, and Janice L. Robertson

Journal of Molecular Biology, Volume 433, Issue 8, 16 April 2021, 166886

https://doi.org/10.1016/j.jmb.2021.166886

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Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

Rahul Chadda, Nathan Bernhardt, Elizabeth G Kelley, Susana CM Teixeira, Kacie Griffith, Alejandro Gil-Ley, Tuğba N Öztürk, Lauren E Hughes, Ana Forsythe, Venkatramanan Krishnamani, José D Faraldo-Gómez, and Janice L Robertson

eLife, 2021 Apr 02.

DOI: 10.7554/eLife.63288

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Occupancy distributions of membrane proteins in heterogeneous liposome populations

Lucy Cliff, Rahul Chadda & Janice L. Robertson

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2020 Jan 01. https://doi.org/10.1016/j.bbamem.2019.183033. Posted on bioRxiv June 02, 2019; https://doi.org/10.1101/657098

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Membrane physiologists of all kinds meet at Woods Hole

Janice L. Robertson & José D. Faraldo-Gómez

Journal of General Physiology, 2019 Feb 22; pii: jgp.201912340. https://doi.org/10.1085/jgp.201912340

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Interrogating the conformational dynamics of BetP transport

Janice L. Robertson

Journal of General Physiology, 2019 Feb 13; pii: jgp.201812315. https://doi.org/10.1085/jgp.201812315

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The LIPID BILAYER AND ITS PROTEIN CONSTITUENTS

Janice L. Robertson

Journal of General Physiology, 2018 Sep 25; pii: jgp.201812153. https://doi.org/doi: 10.1085/jgp.201812153

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A model-free method for measuring dimerization free energies of CLC-ec1 in lipid bilayers

Rahul Chadda, Lucy Cliff, Marley Brimberry & Janice L. Robertson

Journal of General Physiology, 2018 Feb 5; 150(2):355-365. https://doi.org/10.1085/jgp.201711893. Posted on bioRxiv June 23, 2017; https://doi.org/10.1101/154286

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Commentary: Karen G. Fleming, “Taking deterministic control of membrane protein monomer–dimer measurements”, Journal of General Physiology, 2018 Feb 5; 150 (2): 181. https://doi.org/10.1085/jgp.201711913

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The FtsLB sub-complex of the bacterial divisome is a tetramer with an uninterrupted FtsL helix linking the transmembrane and periplasmic regions

Condon SGF✢, Mahbuba DA✢, Armstrong CR, Dias-Vazquez G, Craven SJ, LaPointe LM, Khadria AS, Chadda R, Crooks JA, Rangarajan N, Weibel DB, Hoskins AA, Robertson JL, Cui Q & Senes A

J Biol Chem. 2017 Dec 12, doi: 10.1074/jbc.RA117.000426 ✢Shared first authorship.

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Cellular encoding of Cy dyes for single-molecule imaging

Leisle L, Chadda R, Lueck JD, Infield DT, Galpin JD, Krishnamani V, Robertson JL & Ahern CA

eLife 2016; 10.7554/eLife.19088.

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Measuring Membrane Protein Dimerization Equilibrium in Lipid Bilayers by Single-Molecule Fluorescence Microscopy

Rahul Chadda & Janice L. Robertson

Methods Enzymol. 581:53-82. https://doi.org/10.1016/bs.mie.2016.08.025

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The dimerization equilibrium of a clc Cl-/H+ antiporter in lipid bilayers

Rahul Chadda, Venkatramanan Krishnamani, Kacey Mersch, Jason Wong, Marley Brimberry, Ankita Chadda, Ludmila Kolmakova-Partensky, Larry J. Friedman, Jeff Gelles & Janice L. Robertson

eLife 2016 Aug 3; 10.7554/eLife.174382016. https://doi.org/10.7554/eLife.17438.001

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A family of fluoride-specific ion channels with dual-topology architecture

Randy Stockbridge, Janice L. Robertson, Ludmila Kolmakova-Partensky & Christopher Miller

eLife 2013, 2013;2:e01084. https://doi.org/10.7554/eLife.01084

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Nano-Positioning System for Structural Analysis of Functional Homomeric Proteins in Multiple Conformations

Hyde HC, Sandtner W, Vargas E, Dagcan A, Janice L. Robertson, Roux B, Correa A M & Bezanilla F.

Structure 2012, 20(10):1629-40. https://doi.org/10.1016/j.str.2012.08.022

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Multi-ion distributions in the cytoplasmic domain of inward-rectifier potassium channels

Janice L. Robertson, Lawrence G. Palmer & Benoit Roux

Biophysical Journal 2012, 103(3), 434–443. https://doi.org/10.1016/j.bpj.2012.06.023

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Ion access pathway to the transmembrane pore in P2X receptor channels

Kawate T, Janice L. Robertson, Li M, Silberberg SD, and Swartz KJ

Journal of General Physiology 2011, 137(6):579-90. https://doi.org/10.1085/jgp.201010593

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Structure of a slow ClC transporter from cyanobacteria

Jayaram H, Janice L. Robertson, Wu F, Williams C & Miller C.

Biochemistry 2011, 50(5):788-94. https://doi.org/10.1021/bi1019258

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Design, function and structure of a monomeric ClC transporter

Janice L. Robertson, Ludmila Kolmakova-Partensky & Christopher Miller

Nature 2010, 468(7325):844-7. https://doi.org/10.1038/nature09556

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Structure of cytoplasmic pentameric pore of ZntB transporter from V. parahaemolyticus

Tan K, Sather A, Robertson JL, Moy S, Roux B & Joachimiak A.

Protein Science 2009, 18(10): 2043-52. https://doi.org/10.1002/pro.215

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Long-pore electrostatics in inward-rectifier potassium channels

Robertson JL, Palmer LG & Roux B

Journal of General Physiology 2008, 132(6):613-32. https://doi.org/10.1085/jgp.200810068

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Carboxy-terminal determinants of conductance in inward-rectifier K+ channels

Zhang YY, Robertson JL, Gray DA & Palmer LG

Journal of General Physiology 2004, 124(6):729-39. https://doi.org/10.1085/jgp.200409166

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